Tempe Kedelai (Rhizopus oligosporus) sebagai Alternatif Anti Inflamasi

  • Athiyya Husna
  • Emriadi Emriadi
  • Bambang Ristiono
Keywords: Anti-Inflammatory, Inflammatory Mediator, Soybean Tempeh (R. oligosporus)

Abstract

Background: Inflammation is a protective mechanism of the immune system due to tissue damage caused by infectious and non infectious agents. The most widely used synthetic drugs in treating the inflammation is NSAIDs (Non Steroidal Anti Inflammatory Drugs) but long-term use of NSAIDs can cause undesirable side effects. Tempeh (R. oligosporus) is one of the processed soy products that is made through the fermentation process by Rhizopus sp. Tempeh has many benefits for health, one of which is anti-inflammatory. According to some research results, tempeh is recognized as having an anti-inflammatory role. The mechanism of tempeh as an anti-inflammatory, namely by maintain a balance between reactive oxygen species (ROS) and antioxidants in the body, increasing the production of anti-inflammatory cytokines (IL-10), suppressing the activation of NF-kB. This process can suppress the expression of iNOS and COX-2 and inhibit several inflammatory mediators, such as TNF-α, IL-1β and NO. Objective: The purpose of this study was to investigate anti-inflammatory activity of soybean tempeh (R.oligosporus) and find out the potential of active compounds in soybean tempeh that play role as anti-inflammatory. Method: The study was conducted by collecting and examining of various literatures on potential of soybean tempeh (R.oligosporus) in suppressing inflammatory response. Conclusion: The active compounds found in soybean tempeh (R. oligosporus) is able to suppress the inflammatory response.

References

Abusharib, A. B. General Pathology Made Easy. 2nd ed. Saudi Arabia: Najran University; 2017.

Abdulkhaleq, L.A., Assi, M. A., Abdullah, R., Zamri-Saad, M., Taufiq-Yap,Y. H., & Hezmee, M. N. M. The Crucial Roles of Inflammatory Mediators in Inflammation: A Review. Veterinary World. 2018; 11(5): 627-635.

Adie, M. M., & Krisnawati, A. Biologi Tanaman Kedelai. Dalam Kedelai: Teknik Produksi dan Pengembangan. Sumarno, Suryamto, A. Widjono, Hermanto, dan H. Kasim. Malang: Badan Penelitian dan Pengembangan Pertanian. 2007.

Aguiar, C. L. Effects of Processing Techniques on Isoflavones Profil: A Review. In Isoflavones: Biosynthesis, Occurrence and Health Effects. Melanie, J. T. USA: Nova Publisher. 2010.

Agung,V I. A. A. Tempeh Juice As a Potential Health Support Culinary Tourism. Journal of Business on Hospitality and Tourism. (2016); 2(1): 363-366.

Ahmed, A. U. An Overview of Inflammation: Mechanism and Consequences. Front Biol. 2011; 6(4): 274-281.

Al-kaf, A. Nonsteroidal Anti-Inflammatory. Rijeka: Intech. 2018.

Antonelli, M., & Kushner, I. It's Time to Redefine Inflammation. The Faseb Journal. 2017; 31: 1787-1791.

Ashley, N. T., Weil, Z. M., & Nelson, R. J. Inflammation: Mechanism, Costs and Natural Variation. Annual Review Evol. Syst. 2012; 12(43): 385-406.

Bjarnason, I., et al., A. Mechanism of Damage to the Gastrointestinal Tract From Non-Streoidal Anti-Inflammatory Drugs. Gastroenterology. 2017; 155(4):1271-1273.

Braunersreuther, V., et al., Role of Cytokines and Chemokines in Non Alcoholic Fatty Liver Disease. World Journal of Gastroenterology. 2012; 18(8): 727-735.

Cai, S., et al., Evaluation of γ-aminobutyric Acid, Phytate and Antioxidant Activity of Tempeh-like Fermented Oats (Avena Sativa L.) Prepared with Different Filamentous Fungi. J Food Sci Technol. 2012; 51: 2544-2551.

Cao, Z. H., Green-Johnson, J. M., Buckley, N. D., & Lin, Q. Y. Bioactivity of Soy-based Fermented Foods: A Review. Biotechnology Advances. 2019; 37(1): 223–238.

Chaiyasut, C., Kumar, T., Tipduangta, P., & Rungseevijitprapa, W. Isoflavone Content and Antioxidant Activity of Thai Fermented Soybean and Its Capsule Formulation. African J Biotechnol. 2010; 9: 4120–4126.

Chiang, M. C., Nicol, C. J., & Cheng, Y. C. Resveratrol Activation of AMPK-dependent Pathways is Neuroprotective in Human Neural Stem Cell Against Amyloid-beta-induced Inflammation and Oxidative Stress. Neurochemistry International. 2018; 115: 1-10.

Chen, L., et al., Inflammatory Responses and Inflammation Associated Diseases in Organs. Oncotarget. 2018; 9(6): 7204–7218.

Choi, J., Kwon, Sun-Hwa., Park, Kun-Young., Yu, B. P., Kim, N. D., Jung,. J. H., & Chung, H. Y. The Anti-Inflammatory Action of Fermented Soybean Products in Kidney of High-Fat-Fed Rats. Journal of Medical Food. 2011;14(3): 232-239.

Danciu, C., Avram, S., Pavel, I. Z., Ghiulai, R., Dehelean, C. A., Ersilia, A., Minda, D., Petrescu, C., Moaca, E. A., & Soica, C. Main Isoflavones Founds in Dietary Sources as Natural Anti-Inflammatory Agents. Current Drug Targets. 2018; 19(7): 841-853.

Danciu, C, Soica, C., Csanyi, E., Ambrus, R., Feflea, S., & Peev, C. Change in The Anti Inflammatory Activity of Soy Isoflavonoid Genistein versus Genistein Incorporated in Two Types Cyclodextrine Derivates. Chemistry Central Journal. 2012; 6(1): 1.

Dewi, R. Stia & Aziz, S. Isolasi Rhizopus oligosporus pada Beberapa Inokulum Tempe di Kabupaten Banyumas. Molekul. 2011; 6(2): 93-104.

Dinar, F. Manfaat Tempe Terhadap Kesehatan Tubuh. Jurnal Pengabdian Kepada Masyarakat. 2013; 19(71): 1–10.

Fawwaz, M., Natalisnawati, A., & Baits, M. Kadar Isoflavon Aglikon pada Ekstrak Susu Kedelai dan Tempe. Jurnal Teknologi dan Manajemen Agroindustri. 2017; 6(3): 152-158.

Feng, G., Sun, B., & Li, Tian-zuo. Daidzein attenuates Lipopolysaccharide-induced Acute Lung Injury via Toll-Like Receptor 4/ NF-kappaB Pathway. International Immunopharmacology. 2015; 26(2015): 392-400.

Fokunang, C. N., Tembe, E., Frederick, K., & Ngadjui, B. Overview of Non-Steroidal Anti-Inflammatory Drugs ( Nsaids ) in Resource Limited Countries. MOJ Toxicology. 2018; 4(1): 5–13.

Freire, M. O.,& Van Dyke, T. E. Natural Resolution of Inflammation. National Institutes of Health. 2013; 63(1): 149-164.

Fukuda, M., Kobayashi, M., & Honda, Y. Functional Components and Health Benefits of Fermented Soymilk. In Soft Chemistry and Food Fermentation. 2017.

Gamble, C., McIntosh, K., Scott, R., Ho, K. H., Plevin, R., & Paul, A. Inhibitory Kappa B Kinase as Targets for Pharmacological Regulation. British Journal of Pharmacology. 2012; 165: 802-819.

Geering, B., Stoeckel, C., Conus, S., & Simon, H. U. Living and Dying for Inflammation: Neutrophils, Eosinophils, Basophils. Trends Immunols. 2013; 34(8): 398-409.

Ghasemzadeh, A. & Ghasemzadeh, N. Flavonoids and Phenolic Acids : Role and Biochemical Activity In Plants and Human. Journal of Medicinal Plants Research. 2011; 5(31): 6697-6703.

Gurenlian, B. J. R. Inflammation: The Relationship Between Oral Health and Systemic Disease. Colgate. 2016.

Hamad, A., Mani, V., Ramasamy, K., Lim, S. M., & Abdul Majeed, A. B. Memory Enhancement in Rats by Soybean and Tempeh Extracts is Associated with Improved Cholinergic and Reduced Neuroinflammatory Activities. Sains Malaysiana. 2016; 45(9): 1299-1310.

Hamzah, N., Najib, A., Thahir, N., & Misqawati, I. Studi Farmakofor Reseptor COX-2 Sebagai Anti inflamasi. Jurnal Farmasi Fakultas Ilmu Kesehatan UINAM. 2015; 2(3): 99–107.

Hasturk, H., Kantarci, A., & Van Dyke, T. E. Oral Inflammatory Diseases and Systemic Inflammation: Role of The Macrophage. Frontiers in Immunology. 2012; 3(118): 1–17.

Hikmah, Nuzulul., & Dewanti, I. D. A. R. Peran Toll-like eceptors (TLR) pada Innate Immunity. Jurnal Kedokteran Gigi Universitas Jember. 2011; 8(1): 21-26.

Hussana, A. & Suparmi. Potensi Ekstrak Selaput Biji Kesumba (Bixa orellana L.) sebagai Obat Anti Inflamasi. Jurnal Unissula. 2012; 4(2): 134-141.

Hwang, Sung-Min., Chung, G., Kim, Y. H.,& Park, Chul-Kyu. The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration. International Journal of Molecular Sciences. 2019; 20(5849): 1-16.

Hwang, J., et al., Neuroprotective Effects of Tempeh against Lipopolysaccharide-induced damage in BV-2 Microglial Cell. International Journal on Nutrition, Diet, and Nervous System. 2018; 22(12): 840-849.

Imananta, F.P., Sulistyaningsih. Penggunaan NSAIDs (Non Steroidal Anti Inflammatory Drugs) Menginduksi Peningkatan Tekanan Darah pada Pasien Arthtritis. Jurnal Farmaka. 2018; 16(1): 72-79.

Izuegbuna, O., Otunola, G., & Bradley, G. Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities of Opuntia stricta cladodes. PLOS ONE. 2019; 14(1): 1-27.

Jagasia, D & Ferrando, V. Z. Tempeh: a Tempting Potential Vitamin B12 Treat. Thesis. Sweden: Department of Food, Nutrition and Dietetics UPPSALA University. 2015.

Jayachandran, M & Xu, B. An Insight into The Health Benefits of Fermented Soy Products. Food Chemistry. 2018; 271: 362-371.

Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. The Role of Non-Resolving Inflammation in Atherosclerosis. The Journal of Clinical Investigation. 2018; 128(7): 2713-2723.

Kasturi, J., Palla, P. R., Bakshi, V., & Boggula, N. Non-steroidal Anti-Inflammatory Drugs. Journal of Drug Delivery and Therapeutics. 2019; 9(1-s): 442-448.

Kaur, M & Badhan, R.K. Phytoestrogens modulate breast cancer resistance protein expression and function at the blood-cerebrospinal 6 M. Journal of Pharmacy & Pharmaceutical Sciences. 2015; 18: 132– 154.

Krisnawati, A. Soybean as Source of Functional Food. Iptek Tanaman Pangan. 2017; 12(1): 57–65.

Kuligowski, M., Pawlowska, K., Kuligowska, I. J., & Nowak, J. Isoflavone Composition, Polyphenols Content and Antioxidative Activity of Soybean Seeds During Tempeh Fermentation. CyTA-Journal of Food. 2016; 15(1): 27-33.

Kumar, S., Kumar, A., Gupta, V., & Yashavarddhan, M. H. Pharmacological Control of Inflammation in Wound Healing. Journal of Tissue Viability. 2019; 28(4): 1–5.

Mambang, D. E. P., & Suryanto, D. Aktivitas Antibakteri Ekstrak Tempe Terhadap Bakteri Bacillus subtilis dan Staphylococcus aureus [ Antibacterial Activity of Tempe Extracts on Bacillus subtilis and Staphylococcus aureus ]. Jurnal Teknologi dan Industri Pangan IPB. 2014; 25(1): 115-118.

Mani, V., & Ming, L. C. Tempeh and Other Fermented Soybean Products Rich in Isoflavones. In Fermented Foods in Health and Disease Prevention. Frias, J., Martinez-Villaluenga, C., Penas, Elena. United Kingdom: Elsevier. 2017.

Masilamani, M., Wei, J., & Sampson, H. A. Regulation of Immune Response by Soybean Isoflavones. Immunol Res. 2012.

Maskrey, B. H., Megson, I. L., Whitfield, P. D., & Rossi, A. G. Mechanisms of Resolution of Inflammation: A Focus on Cardiovascular Disease Arteriosclerosis, Thrombosis, and Vascular Biology. American Heart Association (AHA) Journal. 2011; 31(5): 1001–1006.

Mawaddah, N., Fakhrurrazi, & Rosmaidar. Aktivitas Antibakteri Ekstrak Tempe Terhadap Bakteri Staphylococcus aureus. Jurnal Ilmiah Mahasiswa Unsyiah. 2018; 2(3): 230-241.

Mohammed, M. S., et al., Secondary Metabolites As Anti-Inflammatory Agents. The Journal of Phytopharmacology. 2014; 3(4): 275-285.

Mohan, H. Textbook of Pathology. 6th ed. India:.Jaypee Brothers Medical Publisher. (2010).

Nidavani, R. B., AM, Mahalakshmi.,& Shalawadi, M. Vascular Permeability and Evans Blue Dye: A Physiological and Pharmacological Approach. Journal of Applied Pharmaceutical Sciences. 2014; 4(11): 106-113.

Nurrani, lis. Pemanfaatan Tradisional Tumbuhan Alam Berkhasiat Obat Oleh Masyarakat di Sekitar Cagar Alam Tangale. Info BPK Manando. 2013; 3(1): 1-22.

Palmblad, J. The Acute Inflammatory Reaction: New Concepts for Old Cells. Journal of Internal Medicine. 2010; 268: 1-4.

Peres, M. F. S., Ribeiro, F. V., Ruiz, K. G. S., Nociti-Jr, F. H., Sallum, E. A., & Casati, M. Z. Steroidal and Non-steroidal Cyclooxygenase-2 Inhibitor Anti-Inflammatory Drugs As Pre-emptive Medication in Patients Undergoing Periodontal Surgery. Brazilian Dental Journal. 2012; 23(6): 621–628.

Primadina, N., Basori, A.,& Perdanakusuma, D.S. Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler. Qanun Medika. 2019; 3(1): 31-42.

Raza, S., Mubeen, H., Anwar, M., & Tahir, A. Evaluation of Physicochemical and Nutritional Content in Soybean Fermented Food Tempeh by Rhizopus oligosporus. Journal of Advance in Biology and Biotechnology. 2018; 17(1): 1-9.

Rosahdi, T. D., Kusmiyati, M., & Wijayanti, F.R. Uji Aktivitas Antioksidan Buah Rambutan Rapiah dengan Metode DPPH. Journal UINSGD. 2013; 7(1): 1-15.

Sirotkin A. V & Harrath A.H. Phytoestrogens and their effects. Eur J Pharmacol. 2014; 741: 230–236.

Soka, S., Suwanto, A., Sajuthi, D., & Rusmana, I. Impact of Tempeh Supplementation on Gut Microbiota Composition in Sprague-Dawley Rats. Research Journal of Microbiology. 2014; 9(4): 189– 198.

Sonwebber, T., Pizzini, A., Nairz, M., Weiss, G., & Tancevski, I. Arachidonic Acid Metabolites in Cardiovascular and Metabolic Disease. International Journal of Molecular Science. 2018; 19(3285): 1-26.

Speer, H., D’Cunha, N. M., Davies, M. J., McKune, A. J., & Naumovski, N. The Physiological Effects of Amino Acids Arginine and Citrulline. MDPI Beverages. 2020; 6(11): 1-11.

Starzyńska-Janiszewska, A., Stodolak, B., & Mickowska, B. Effect of controlled lactic acid fermentation on selected bioactive and nutritional parameters of tempeh obtained from unhulled common bean (Phaseolus vulgaris) seeds. Journal of the Science of Food and Agriculture. 2014; 94(2): 359–366.

Subbaiah, R., Thomas, B., V.P. Maitheyi. Self-Inflicted Traumatic Injuries of The Gingiva - A Case Series. Journal International Oral Health. 2010; 2(2): 44-50.

Suzuki, Katsuhiko. Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise. Journal of Biomolecules. 2019; 9(223): 1-11.

Szliszka E., Skaba D., Czuba ZP., & Krol W. Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages. Molecules. 2011; 16(5):3701–3712.

Trikoso, N. Penggunaan Kortikosteroid dan Obat Anti Inflamasi Non Steroid.(April). 2016.

Uribe-Henao, A. F., Arboleda-Monsalve, L. G., Velasquez-Perez, A., Zapata-Medina, D. G., & Sarabia, F. Tempe. Geotechnical Special Publication. Mar 2018; (GSP 297): 12–22.

Vural, A., Shi, C. S., & Kehrl, J. H. Toll-like Receptors Serve as Activators for Autophagy in Macrophages Helping to Facilitate Innate Immunity. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Aging. Autophagy. 2015; 6: 179-189.

Ward, Peter A. Acute and Chronic Inflammation. In Fundamental of Inflammation. London: Cambridge University Press. 2018.

Warta Ekspor. Obat Herbal Tradisional. Jakarta: Ditjen PEN/MJL/005/11 September. 2014.

Wilmana P. Freddy., Gan, Sulistia. Analgesik-Antipiretik Analgesik Anti-Inflamasi Nonsteroid dan Obat Gangguan Sendi Lainnya. Dalam Farmakologi dan Terapi Cetakan Ulang dengan Tambahan). Gunawan Gan, Sulistia. Jakarta: Fakultas Kedokteran Universitas Indonesia. 2012.

Winarsi, H., Purwanto, A., & Dwiyanti, H. Kandungan Protein dan Isoflavon pada Kedelai dan Kecambah Kedelai. Biota. 2010; 15(2): 181-187.

Xu, W. & Larbi, A. Immunity and Inflammation: From Jekyll to Hyde. In Experimental Gerontology. Singapore: Elsevier. 2017.

Yuliani, S. H., Gani, M. R., Istyastono, E. P., & Riswanto, F. D. O. Optimization of Genistein and Daidzein Extraction From a Tempeh-Fermented Product of Soybean. Journal of Pharmacy and Pharmacognosy Research. 2018; 6(4): 231-241.

Yuliani, S. H., Sandrapitaloka, A. S., Restiana, F. R., Tosan Aji, P. D., Gani. M. R., Octa Riswanto, F. D. Effects of Paticle Size, Extraction Time and Solvent of Daidzein Yield Extracted From Tempeh. Jurnal Farmasi Sains dan Komunitas. 2019; 16(1): 44-49.

Yulifianti, R., Muzaiyanah, S., & Utomo, J. S. Kedelai sebagai Bahan Pangan Kaya Isoflavon. Buletin Palawija. 2018; 16(2): 84.

Yu, J., Bi, X., Yu, B., & Chen, D. Isoflavones: Anti-inflammatory Benefit and Possible Caveats. Nutrients Journal. 2016; 8(6): 1–16.

Yusof et al. Anti-Inflammatory, Analgesic and Acute Toxicity Effects of Fermented Soybean. BMC Complementary and Alternative Medicine. 2019; 19:373.

Yusof et al. Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcoholi-Induced Liver Damage in Mice. Hindawi: Evidence-Based Complementary and Alternative Medicine. 2013; (274274): 1-8.

Zaheer, K. & Akhtar, M. H. An Updated Review of Dietary Isoflavones: Nutrition, Processing, Bioavailability and Impact on Human Health. Critical Review in Food Science and Nutrition. 2017; 0(0): 1-14.

Zetoune, FS., Serhan, CN., Ward, PA. Inflammatory Disorder. In The Comprehensive Pharmacology Reference. US: Elsevier. 2014.

Published
2021-12-01
How to Cite
Husna, A., Emriadi, E., & Ristiono, B. (2021). Tempe Kedelai (Rhizopus oligosporus) sebagai Alternatif Anti Inflamasi. Andalas Dental Journal, 9(2), 100-117. https://doi.org/10.25077/andalas dent. j.v9i2.183

Most read articles by the same author(s)